These prodrugs provided longer residence time of an effective PPI plasma concentration, resulting in better gastric acid inhibition. New arylsulfonyl proton pump inhibitor ( PPI) prodrug forms were synthesized. Shin, Jai Moo Sachs, George Cho, Young-moon Garst, Michael The clinical potential of dietary inulin treatment should be the subject of future studies.ġ-Arylsulfonyl-2-(Pyridylmethylsulfinyl) Benzimidazoles as New Proton Pump Inhibitor Prodrugs In contrast, inulin did not increase intestinal absorption of Mg2+ sufficiently to recover serum Mg2+. This study suggests that dietary inulin counteracts reduced intestinal Ca2+ absorption upon PPI treatment. Additionally, intestinal and renal mRNA levels of the Trpm6 gene were reduced after inulin intake. Inulin abolished enhanced expression of Trpv6 and S100g in the colon by omeprazole. However, concomitant addition of dietary inulin fibers normalized serum Ca2+ but not serum Mg2+ concentrations. Treatment with omeprazole significantly reduced serum Mg2+ and Ca2+ levels. Moreover, the mRNA levels of magnesiotropic and calciotropic genes were examined in the large intestine and kidney by real-time PCR. Subsequently, Mg2+ and Ca2+ homeostasis was assessed by means of serum, urine and fecal electrolyte measurements. Here, C57BL/J6 mice were supplemented with omeprazole and/or inulin. This study aimed, therefore, to improve mineral absorption by application of dietary inulin to counteract PPIH. Fermentation of dietary oligofructose-enriched inulin fibers by the microflora leads to acidification of the intestinal lumen and by this enhances mineral uptake. It is hypothesized that PPIs reduce epithelial proton secretion and thereby increase the pH in the colon, which may explain the reduced absorption of and Mg2+ and Ca2+. Additionally, PPIH is associated with hypocalcemia and hypokalemia. Proton-pump inhibitor-induced hypomagnesemia (PPIH) is the most recognized side effect of proton-pump inhibitors (PPIs). Hess, Mark W de Baaij, Jeroen H F Gommers, Lisanne M M Hoenderop, Joost G J Bindels, René J M We investigated PPI use after ARS in the general Danish population using nationwide.ĭietary Inulin Fibers Prevent Proton-Pump Inhibitor ( PPI)-Induced Hypocalcemia in Mice. Data from clinical trials on PPI use after ARS have been conflicting. Objective Antireflux surgery (ARS) has been suggested as an alternative to lifelong use of proton pump inhibitors ( PPI) in reflux disease. Use of proton pump inhibitors after anti-reflux surgery
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